Global Respiratory Syncytial Virus – Related Infant Community Deaths – CHAMPS Health
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Clinical Infectious Diseases (Gates Supplement) 2021 https://doi.org/10.1093/cid/ciab528

Global Respiratory Syncytial Virus – Related Infant Community Deaths

Citation activity 40 total
Y8 13 Y9 16 Total 40

Abstract

2021 Year
13 Y8 Citations
40 Citations
16 Y9 Citations
Network-wide (all sites) CHAMPS Site

Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.

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Problem Research context

Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries.

Finding Evidence signal

At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.The RSV Global Online Mortality Database (RSV GOLD), a global registry…

Implication Action pathway

RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement.

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Mazur, N. I., Löwensteyn, Y. N., Willemsen, J. E., Gill, C. J., Forman, L., Mwananyanda, L. M., Blau, D. M., Breiman, R. F., Madhi, S. A., Mahtab, S., Gurley, E. S., El Arifeen, S., Assefa, N., Scott, J. A. G., Onyango, D., Tippet Barr, B. A., Kotloff, K. L., Sow, S. O., Mandomando, I., … Bont, L. J. (2021). Global respiratory syncytial virus–related infant community deaths. Clinical Infectious Diseases, 73(Supplement_3), S229–S237. https://doi.org/10.1093/cid/ciab528
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