CHAMPS SITE
PUBLICATION DATE
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Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh
BangladeshPLOS Global Public Health2025Cite ShareMutevedzi PC, Madewell ZJ, Kotloff KL, Bassat Q, Chirinda PJ, et al. (2025) Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh. PLOS Global Public Health 5(6): e0004772. https://doi.org/10.1371/journal.pgph.0004772
Achieving the Sustainable Development Goal of reducing child mortality to <25 deaths per 1000 live births by 2030 requires strategies to prevent diarrheal disease-related morbidity and mortality. Accurate etiological diagnosis is essential. This study used postmortem diagnostics to investigate the contribution of diarrhea to under-5 mortality and examine co-morbidities and…
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Post-mortem study of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in deaths of children under five in low- and middle-income countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) study
Bangladesh, Ethiopia, Kenya, Mozambique, Nigeria, Pakistan, Sierra Leone, and South AfricaJournal of Clinical Virology2025Cite ShareBaillie, V., Dangor, Z., Blau, D. M., Mahtab, S., Du Toit, J., Assefa, N., Oundo, J., Kidanemariam, Z. T., Scott, J. A. G., Ameh, S., Ogbuanu, I. U., Ojulong, J., Bunn, J., Kotloff, K. L., Sow, S. O., Tapia, M. D., Keita, A. M., Garrine, M., Mandomando, I., . . . Madhi, S. A. (2025). Post-mortem study of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in deaths of children under five in low- and middle-income countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) study. Journal of Clinical Virology, 178, 105804. https://doi.org/10.1016/j.jcv.2025.105804
Background:Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death.Methods:We evaluated pediatric deaths from January 2017 through December 2022. A panel of experts determined the cause of death (CoD) by reviewing available data, including…
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A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022
KenyaPLOS Global Public Health2025Cite ShareGachau, S., Akelo, V., Cleveland, A., Were, J., Khagayi, S., Kwaro, D., Taegtmeyer, M., Obor, D., Igunza, A., Munga, S., Omore, R., Misore, T., Aol, G., Onyango, D., Tippett Barr, B. A., & Joseph, R. (2025). A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022. PLOS Global Public Health, 5(5), e0004338. https://doi.org/10.1371/journal.pgph.0004338
The impact of the COVID-19 pandemic on pediatric mortality, including measures to ensure continuity of HIV care, is not well described in Kenya. We evaluated causes of death (COD) among decedents under 5 years of age both before and during the COVID-19 pandemic in Kenya. We analyzed Child Health and…
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Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries
Multiple sitesJAMA Network Open2025Cite ShareRahman, A., Ray, M., Madewell, Z. J., Igunza, K. A., Akelo, V., Onyango, D., Murila, F., Mwebia, W., Ogbuanu, I. U., Ojulong, J., Kowuor, D., Kaluma, E., Samura, S., El Arifeen, S., Gurley, E. S., Hossain, M. Z., Islam, K. M., Biswas, R., Assefa, N., . . . Rees, C. A. (2025). Adherence to perinatal asphyxia or sepsis management guidelines in low- and middle-income countries. JAMA Network Open, 8(5), e2510790. https://doi.org/10.1001/jamanetworkopen.2025.10790
Key Points Question Do neonates who die of perinatal asphyxia or sepsis in low- and middle-income countries receive guideline-adherent clinical care? Findings In this cross-sectional study of 1194 neonates who died, less than 5% of those who died with perinatal asphyxia received all recommended clinical care, and 61% of those who died…
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Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study
Network-wide (all sites)BMJ Journal2025Cite ShareDas, P. M., Madewell, Z. J., Blau, D. M., Whitney, C.G., Ramakrishnan, U, Stein, A.D., Young, M.F, & Suchdev, P.S. (2025). Importance of postmortem anthropometric evaluation in defining the role of malnutrition as a cause of infant and child deaths in Sub-Saharan Africa and South Asia: a cohort study. BMJ Open, 15(e089874). https://doi.org/10.1136/bmjopen-2024-089874
Objectives: To evaluate how postmortem anthropometric malnutrition (PAM) measures align with expert panel attribution of malnutrition as a causal or significant condition in under-5 mortality (U5M). Design: Cohort study using data from the Child Health and Mortality Prevention Surveillance network, incorporating clinical records, postmortem anthropometrics, minimally invasive tissue sampling, clinical abstraction and…