CHAMPS SITE
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh
BangladeshBMC Microbiology2025Cite ShareAlam, M., Islam, M. S., Jahan, M. I., Deb, A. S., Rahman, A., Islam, Z., Chowdhury, A. I., Islam, K. M., Hossain, M. Z., Ahmed, D., Arifeen, S. E., Gurley, E. S., & Rahman, M. (2025). A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh. BMC Microbiology, 25, Article 61. https://doi.org/10.1186/s12866-024-03650-5
Background Listeria monocytogenes is a foodborne pathogen that can lead to severe pregnancy outcomes. This study reports the clinical and genomic characteristics of a Listeria-mediated stillbirth identified in January 2022 through the Child Health and Mortality Prevention Surveillance (CHAMPS) project in Bangladesh. The Lm-BD-CHAMPS-01 isolate was recovered from the blood and cerebrospinal fluid…
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Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries
Sierra leon, South Africa, Bangladesh,JAMA Network Open2025Cite ShareRahman A, Ray M, Madewell ZJ, et al. Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries. JAMA Netw Open. 2025;8(5):e2510790. doi:10.1001/jamanetworkopen.2025.10790
Importance: Most of the 2.3 million annual neonatal deaths occur in sub-Saharan Africa and South Asia, with perinatal asphyxia and neonatal sepsis being the leading causes of neonatal mortality. Most neonatal deaths are considered preventable through high-quality clinical care, which includes adherence to clinical care guidelines. Objective: To assess adherence…
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Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh
BangladeshPLOS Global Public Health2025Cite ShareMutevedzi PC, Madewell ZJ, Kotloff KL, Bassat Q, Chirinda PJ, et al. (2025) Use of minimally invasive tissue sampling to determine the contribution of diarrheal diseases to under-five mortality and associated co-morbidities and co-infections in children with fatal diarrheal diseases in Africa and Bangladesh. PLOS Global Public Health 5(6): e0004772. https://doi.org/10.1371/journal.pgph.0004772
Achieving the Sustainable Development Goal of reducing child mortality to <25 deaths per 1000 live births by 2030 requires strategies to prevent diarrheal disease-related morbidity and mortality. Accurate etiological diagnosis is essential. This study used postmortem diagnostics to investigate the contribution of diarrhea to under-5 mortality and examine co-morbidities and…
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Post-mortem study of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in deaths of children under five in low- and middle-income countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) study
Bangladesh, Ethiopia, Kenya, Mozambique, Nigeria, Pakistan, Sierra Leone, and South AfricaJournal of Clinical Virology2025Cite ShareBaillie, V., Dangor, Z., Blau, D. M., Mahtab, S., Du Toit, J., Assefa, N., Oundo, J., Kidanemariam, Z. T., Scott, J. A. G., Ameh, S., Ogbuanu, I. U., Ojulong, J., Bunn, J., Kotloff, K. L., Sow, S. O., Tapia, M. D., Keita, A. M., Garrine, M., Mandomando, I., . . . Madhi, S. A. (2025). Post-mortem study of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in deaths of children under five in low- and middle-income countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) study. Journal of Clinical Virology, 178, 105804. https://doi.org/10.1016/j.jcv.2025.105804
Background:Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death.Methods:We evaluated pediatric deaths from January 2017 through December 2022. A panel of experts determined the cause of death (CoD) by reviewing available data, including…
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A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022
KenyaPLOS Global Public Health2025Cite ShareGachau S, Akelo V, Cleveland A, Were J, Khagayi S, et al. (2025) A comparison of all-cause and HIV cause-specific mortality among children under 5 years of age before and during COVID-19 in Kenya, 2018–2022. PLOS Global Public Health 5(5): e0004338. https://doi.org/10.1371/journal.pgph.0004338
The impact of the COVID-19 pandemic on pediatric mortality, including measures to ensure continuity of HIV care, is not well described in Kenya. We evaluated causes of death (COD) among decedents under 5 years of age both before and during the COVID-19 pandemic in Kenya. We analyzed Child Health and…